Wednesday, August 26, 2020

Humanities Essay Example | Topics and Well Written Essays - 750 words

Humanities - Essay Example The imagination, radiance, and wistful impacts associated with the fine art makes them important. Various occasions in history have offered ascend to various works of art (Charles and Metcalf, 2007). One of the old occasions, known by the name of Renaissance existed from fifteenth to seventeenth hundreds of years and the eighteenth century craftsmanship developed under the name of neoclassical workmanship. Renaissance is a word that went under the inference from French language that implies reawakened. A social and taking in resurrection that started from Florence - Italy, arrived at the limits of Europe later on. The craftsmanship in this time was heightening with an interesting, elite, and diverse style as works of art and figure making, which went under the name of Renaissance workmanship. This period not just gave an alternate importance to the field of expressions however reasoning, writing, music, and science saw a monstrous change and upgrades. Renaissance workmanship brought forth new structures and methods of compositions that influenced the specialists through its work as well as average citizens also went under warmth by it (Charles and Metcalf, 2007). Renaissance craftsman began to make compositions on particular subjects and genuine pictures depicting human wonderful and life’s satisfaction came into concentrate as opposed to confining themselves to just strict artworks. The craftsmen concentrated on minute subtleties of the article from various points and separations while painting or making figures. The compositions of medieval times that concentrated on solid and erect bodies came into substitution by genuine canvases (Charles and Metcalf, 2007). The time of Renaissance brought forth indigenous craftsmen, for example, the notable Leonardo da Vinci, Michelangelo, and Raphael. Leonardo da Vinci with the utilization of oil paint improved his canvases that primarily centered around scenes, normal items, and people. He remembered minute subtle ties for every one of his artistic creations and one of his most appreciated works of art incorporates Mona Lisa and The Last Supper. Michelangelo just focused on human body in his work of art and the marble sculpture of David is his acclaimed creation. In the High Renaissance time frame, Raphael has likewise contributed in his show-stopper. Indeed, he was well known for his pictures of the aristocrats of that time and his prestigious workmanship incorporates representation of Pope Julius II and Pope Leo X (Books, 2010). Taking a gander at the opposite finish of the range, the eighteenth century craftsmanship brought forth another structure, known as neoclassical workmanship, by and large found in artistic creations, representations, models, and view/scene. The approach of neoclassical craft of the eighteenth century was from France. Effortlessness, straightforwardness, and authenticity were the key highlights of neoclassical workmanship. Naturalism likewise went under concentration in the neoclassical workmanship like that of Renaissance craftsmanship (Books, 2010). This fine art went under impact by the antiquated thoughts and specialists coordinated these motivations with their considerations and perceptions in their representations and works of art. Portrayal of the subjects as images and codes turned into a main viewpoint in the fine art of the specialists to communicate their contemplations, feelings, and perspectives. Eighteenth century compositions and representations didn't mirror the thoughts of brutality, unprofessionalism, and intolerance. Artists’ weaved their dreams, dreams and motivations well with the splendid and beautiful pictures (Buser, 2006). The time of neoclassical craftsmanship has seen numerous dexterous specialists that were very much qualified, tasteful, and refined. A portion of the incredible craftsmen of this

Saturday, August 22, 2020

Environmental issues in Blue Mountains †MyAssignmenthelp.com

Question: Talk about the Environmental issues in Blue Mountains. Answer Natural issues in Blue Mountains The Blue Mountains district is one of the delightful mountain locales in New South Wales in Australia. These mountains are the comprised of the scope of mountains, levels and ledges that stretches out to the Great Dividing Range in Australia (Blue Mountains | Sydney, Australia - sydney.com, 2017). As of late, it has been confronting some natural issues or concerns. These issues have been powerful in the promoting and drawing in vacationers for their industry (Blue Mountains | Sydney, Australia - sydney.com, 2017). The major natural issues are there alongside the political, financial, social, mechanical and lawful components (Holden, 2016). The ecological powers in the travel industry have a significant effect in the molding of the advertising blend. The commercial, advancement and the value ranges for the travel industry must be tended to in such way that the visitors become keen on this. It is significant for the travel industry to concentrate on the preservation of the common areas. This is significant for that specific industry than the other business. Condition is the factor that draws in the guests (Holden, 2016). It is the equivalent in the event of Blue Mountains also. Transport is another worry in the natural issue with respect to the travel industry. The high pace of transport utilization will be a lot of significant for this industry. These vehicle vehicles emanate a lot of the ozone depleting substances while they travel colossal separations in shorter periods. Vacationers coming to Blue Mountains are likewise needing the vehicle vehicles and it is certainly imperative to present eco-accommodating vehicles for the guests here (Holden, 2016). The ecological corruption can be stayed away from along these lines. The more ecologically supportable vehicles ought to be readied that will take into account the maintainability of the earth. Besides, ecotourism ought to be energized as it authorizes a more advantageous condition for the guests and travelers. Business state of Blue Mountains It is critical to discover the qualities, shortcomings and chances to evaluate the business state of the Blue Mountains. These are the most significant things all the while with the goal that the association can draw in more visitors available to them (Forsyth et al., 2014).The impacts of globalization has put some significant effects on the travel industry and influenced the business conditions all in all. Legislative issues, financial aspects, common habitat, Government strategies and laws hugy affect the business conditions. These things influence the business a great deal. The travel industry falls in this line as well. Qualities The monetary administration strategies of Blue Mountains are exceptionally solid and this provides food for the necessities of the economy. They are an unmistakable brand in the zone and the world on the loose. This will be useful to manufacture a superior ubiquity for them (Forsyth et al., 2014). Their client care is agreeable and excellent. This records for a manageable future. The quality control the board is likewise superb in this association. Shortcomings Their site is exceptionally frail and in this way it doesn't contain the correct data constantly. Their essence in the online networking isn't alright and they don't refresh their site every once in a while (Forsyth et al., 2014). Openings They can grow their site for a superior assistance. They should focus to teach their clients. They should grow their offices also. They ought to make developing markets in different nations (Cavusgil, Ghauri Akcal, 2012). Dangers They have countless contenders. Their customers don't comprehend the contrast between sanitized water and characteristic spring water. References Blue Mountains | Sydney, Australia - sydney.com. (2017). In.sydney.com. Recovered 5 September 2017, from https://in.sydney.com/goals/blue-mountains Cavusgil, S. T., Ghauri, P. N., Akcal, A. A. (2012).Doing business in developing markets. Sage. Forsyth, P., Dwyer, L., Spurr, R., Pham, T. (2014). The effects of Australia's takeoff charge: Tourism versus the economy?.Tourism Management,40, 126-136. Holden, A. (2016).Environment and the travel industry. Routledge.

Wednesday, August 12, 2020

How to take the Bebras Computing Challenge this fall

How to take the Bebras Computing Challenge this fall The Bebras Computing Challenge (American homepage, international homepage) is an international challenge that introduces students to computational thinking. Founded in Lithuania in 2004, it has now spread to more than 30 countries and includes hundreds of thousands of student participants, including ~15k in the United States last year. Bebras USA is led by  Eljakim Schrijvers, the lead coach of the Dutch team at the International Olympiad in Informatics, and Rob Kolstad, the former lead coach of the American IOI team. I first heard about Bebras while hanging out with Rob earlier this summer, and learned more from Kim when I saw him at IOI. One thing I like about Bebras USA is that it has really has taken root in the midwest and mountain states, which have not historically been as well-served by computer science enrichment programs as the coasts. I like Bebras focus on accessibility, both in terms of geographic outreach but also its structure of different divisions, beginning from very rudimentary to very advanced. It also provides data to the schools where the challenge is proctored to help them identify aptitude, understand how students are developing, and see where their students can use additional assistance. Plus, Bebras mascot is the beaver, just like (and for the same reasons as) ours. Last week, Daphne from Bebras sent an email blast to the Computer Science Teachers Association, to help let teachers know about the challenge and how they can register their schools for the exam. Ive reproduced the announcement below. If youre an American computer science or math teachers, you should consider signing up; if youre a student or a parent, you could forward this to your math or science teacher and suggest they consider signing up. If youre not an American any-of-these, you can find your countrys organizational information here. In 2014, almost a million participants across 34 countries participated in the Bebras Computing Challenge. Its a free quiz that requires no studying or preparation, and showcases the key computing concepts to participants. This year, its available between 9 20 November and sports an entirely new set of fascinating challenges. The Bebras Challenge is a fun, online event that lets participants apply logical and computational thinking to solve 15 different tasks within 45 minutes. It demonstrates how integrated computing concepts are in our daily lives it might even motivate some students to pursue the field. Each student gets a score and a certificate, which the teacher can download together with an answer sheet for a classroom discussion of the tasks. Everyone in grades 5-12 can participate, regardless of whether or not they have strong interest or skills in math, science, or computing. There are four different challenges with varied-difficulty and age appropriate tasks to make the challenge a fun experience for everyone. Students can participate on any time in the given two weeks and only need a browser or a computer or tablet with an internet connection. No special setup is required. It takes less than one minute to sign up as a teacher or find previous Bebras tasks online. Questions? Please email Daphne: daphne [at] bebraschallenge [dot] org.

Saturday, May 23, 2020

Police Brutality Essay - 1388 Words

An integral component to the infrastructure of government is law enforcement. In recent years, police abuse has come to the attention of the general public. While citizens worry about protecting themselves from criminals, it has now been shown that they must also keep a watchful eye on those who have been given the responsibility to protect and serve. This paper will discuss the types of police abuse prevalent today, including the use of firearms and recovery of private information. I will also discuss what and how citizens’ rights are violated by the police. We will also explore the measures necessary to protect ourselves from police taking advantage of their positions as law enforcement officers with greater permissive rights than†¦show more content†¦In simple terms, corruption in policing is usually viewed as the misuse of authority by a police officer acting to fulfill personal needs or wants. For a corrupt act to occur, three distinct elements of police corrupti on must be present simultaneously: Misuse of authority. Misuse of official capacity. Misuse of personal attainment. (Kornblum 2006: p 71) It has been said that power inevitably leads to corruption, and it is yet to be recognized that , while there is no reason to suppose that policemen as individuals are any less fallible than other members of society, people are often shocked and outraged when policemen are exposed to violating the law. Not only should officers use brutality in very limited situations, I think that it would help requiring officers to file a written report after any use of physical force, regardless of how seemingly insignificant. Although, if every incidence of police abuse was requested to be reported, how many actually would be? Maybe only those serious enough, as depicted in new guidelines, would make it, leaving some space for officers to exert pressure without crossing serious and abusive policy. Another good tactic to control police brutality is to establish a system to identify officers who have beenShow MoreRelatedThe Causes Of Police Brutality810 Words   |  4 Pages Police brutality remains to be one of the most abused human rights in the US.Police have actet out in ways that have made people wonder â€Å"Are officers of the law really doing there job?† Over takats African Americans have gotten discriminated .But for over 50 years those who are to protect us are not.One of the reasons that The media contributes to police brutality is by leaving some stories untold or even change it which then leaves an false impression for the readers . The Media only reportsRead MoreA Report On Police Brutality1367 Words   |  6 PagesStudent Name Instructor Date Course Police Brutality There is various forms of human rights violation currently in the United States, however; Police abuse remains the most serious of them all. Police brutality is, therefore, the use of excessive force or even unnecessary force by the police while they are dealing with civilians. People are left wondering if the police are doing the jobs they were appointed to do under the law. They act in ways such as the use of guns and pepper sprays to intimidateRead MorePolice Brutality1569 Words   |  7 PagesPersuasive/Policy/Problem/Cause/Solution Central Idea/Thesis: Police brutality should be regulated with greater strength and objectivity. INTRODUCTION I. Police brutality is constantly made known to us all through mass media, but I hadn’t ever taken the time to truly grasp the severity of it until it hit close to home. A. Three weeks ago, a close family friend was brutally beaten in front of his children at a family gathering by the police. B. My purpose is to persuade my audience that police brutality should be regulated with greaterRead MorePolice Brutality And The Police Essay940 Words   |  4 Pages Police brutality refers to the use of excessive force against a civilian. The controversies that surround the topic of police brutality relate to different definitions and expectations over what is meant by excessive force. Indeed, police officers are expressly authorized to use necessary, reasonable force to perform their duties. As Jerome Skolnick, an influential police scholar in the United States, underscores: â€Å"as long as members of society do not comply with the law and resist the police, forceRead MorePolice Brutality And The Police851 Words   |  4 Pagesthe police, your opinion may vary. Let me ask you a question about our police force. But keep this in mind, in October 2015 alone, there was 81 deaths by the police. With that being said, who’s to protect us from whose protecting the block? I don t care who you are, you have to be able to realize nowadays that the police brutality is getting out of hand, that the power surge is growing and growing. Look around, there s an increase of civilians death via cops, an increase of reports of police wrongdoingRead MorePolice Brutality2853 Words   |  12 PagesPolice Protality: Introduction Police brutality has been and continues to be of major concern in society. First of all, police brutality is a term used to describe the excessive use of physical force, assault, verbal attacks or slurs, and threats by any law enforcement officer. Efforts to police communities, throughout history, have been tainted by brutality ans abuse of power to some degree. The term police brutality is commonly used very loosely to any and all forms of policeRead MorePolice Brutality1263 Words   |  6 Pagesï » ¿Police Brutality Did you know that Police brutality is the intentional use of excessive force, usually physical, but potentially also in the form of verbal attacks and psychological intimidation, by a police officer? Despite major improvements in police practices (since 1981) reports of alleged police misconduct and abuse continue to spread through the nation. Police Brutality still goes on around the world today with improvements of enforcing police brutality in police departments. There haveRead MorePolice Brutality1865 Words   |  8 Pagesï » ¿Police Brutality is Prevalent Background Information Over the recent years, police have been one of the organizations to be associated with the largest cases of misconduct. Police brutality can be termed as the process of misuse and abuse of authority by the police. The rising cases of police brutality are causing more harm to the public, compared to the actions perpetrated by real criminals. Although police claim that it’s sometimes necessary to curb crime, the process is illegal and police officersRead MorePolice Brutality Over The Years1458 Words   |  6 PagesIt feels as if nothing has changed about police brutality over the years. The usual cycle is that juries acquit the police, cops get their jobs back, and brutality happens again. One of the most broadcasted cases of police brutality, was the beating of Rodney King. On the night of March 2, 1991, a bystander named George Holiday, videotaped the moment when five officers used excess force on an African American man named Rodney King, beating him with batons as he strugg led on the ground. Also, it wasRead MorePolice Misconduct and Police Brutality985 Words   |  4 Pages We hear about police misconduct case and wonder, Why don’t they do anything to stop this? Many say that we should keep the police officers’ perspective in mind. Others say that these actions are due to racism or post 9/11 paranoia. Whatever the excuse may be for these cases, there should be no need for violence anywhere. Police brutality videos go viral and reveal to the world that it actually happens and that it may happen to you too. This pervades people with fear and anger because their

Tuesday, May 12, 2020

Essay about Urban Homelessness in Canada - 2342 Words

Definition of Homelessness Homelessness can simply be defined as the lack of house or shelter. Hulchanski (n.d.) believes that homelessness is â€Å"a great unresolved political and social problem of our time.† He defines homelessness as: The absence of a place to live (a house or apartment or room - the physical structure) - which includes the absence of belonging to a place and the people living there (a home, in the social/psychological sense). [It refers to] situations in which people lack regular and customary access to adequate and appropriate conventional housing (the physical structures that are designed and intended to be permanent residential accommodation). A person who has no regular place to live stays in†¦show more content†¦At risk of houselessness refers to people who are at grave risk of losing their housing. This group includes â€Å"†¦those facing the risk of losing their shelter either by eviction or the expiry of the lease, with no other possibility of shelter in view. Prisoners or people living in other institutions facing their release and having no place to go to, are considered as part of this population† (Springer, 2000). What Causes Homelessness Springer notes that before people becomes homeless or houseless, they first experienced inadequate housing. Before becoming houseless, many people have been living in substandard housing situations. ...Households with a feeble and perhaps insecure income are likely to live in substandard housing units and might also experience houselessness because of economic difficulties† (Springer, 2000). For Jahiel (1992), homelessness happens not only because of people’s economic difficulties. Jahiel (1992) believes that â€Å"homelessness does not occur in a social vacuum. He argues that the events that make people homeless are initiated and controlled by other people whom our society allows to engage in the various enterprises that contribute to the homelessness of others. The primary purpose of these enterprises is not to make people homeless but, rather, to achieveShow MoreRelatedSolution Of Homelessness In Canada1102 Words   |  5 Pages Department of Housing and Urban Development (Henry et al., 2016), over 500,000 people were homeless in the United States on one given night in January 2016. The Canadian Observatory on Homelessness reported that 35,000 people were homeless in Canada around the same time and that at least 235,000 Canadians experience homelessness at some point in a year (Gaetz et al., 2016). Although both the U.S. and Canada have made some effort toward reducing and ending homelessness, it clearly still remains aRead More The Rise in Youth Homelessness in Canada Essay1180 Words   |  5 PagesToday in Canada, a rise in youth homelessness is being observed across the country. Despite common assumptions, the issue of street youth is not isolated to Toronto or Montreal, but has become pervasive across the country. Although accurate statistics are impossible to come by, the disturbing reality is that both urban centers and rural communities nationwide, are struggling to provide their youth with adequate, affordable housing. Issues surrounding the supply and affordability of housing, combinedRead MoreProblems Associated With Hepatitis C1422 Words   |  6 PagesIntroduction: Indigenous peoples in Canada (First Nations, Inuit and Mà ©tis) are recognized as having a significantly increased hepatitis C disease burden in comparison to non-Indigenous Canadians (Uhanova, Tate, Tataryn, Minuk, 2013). Due to over-representation in many groups considered high-risk for hepatitis C transmission, such as those living in unstable housing or engaging in injection drug use, Indigenous peoples living in urban settings are particularly affected (Miller et al., 2010). RecentRead MoreHomelessness : A Very Real Problem For Canadian Society1769 Words   |  8 Pages1990s, homelessness has emerged as a very real problem for Canadian society. In 2014, it is estimated that over 235,000 different Canadians will experience homelessness in a year, with over 35,000 Canadians homeless on any given night (The State of Homelessness in Canada 2). However, the real problem is hidden in the numbers, where despite only making up 4.3% of the total Canadian population, Aboriginal Peoples represent a disproportionate percentage of the homeless populations across Canada (SOHCRead MoreHousing Services Act Essay795 Words   |  4 PagesThe Housing Services Act is designed to regulate community-based planning and the delivery of housing and homelessness services and to provide for families with low-income resources. This policy has an oversight by the provincial government and offers policy direction. It also has a purpose to provide a flexible service for managers and housing providers to retain requirements with respect to the current housing programs that prelude the Act and housing projects that are focused on the specific programsRead MoreThe Health Care Of Canada1477 Words   |  6 PagesIntroduction: Are Canadians people who are facing homelessness getting the health care that they need in Canada? Most people would think so because Canada has a system of universal health insurance. The World Health Organization(WHO) describes universal health insurance as ensuring that all people can use the promotive, preventive, curative, rehabilitative and palliative health services they need, of sufficient quality to be effective, while also ensuring that the use of these services doesRead MoreHomelessness in the United States Essay1461 Words   |  6 PagesAccording to the National Student Campaign Against Hunger and Homelessness, â€Å"approximately 3.5 million people are homeless each year, while 36.3 million live in households without enough food.† This statistic only reflects the United States, and to many people, it just doesn’t make sense. For instance Alfredzine Black of the YWCA in Marion, Indiana says, â€Å"I don’t understand why we have so much poverty in the richest country in the world!† Citizens of the United States have a hard time defining andRead MoreCanada s Policy Difference Of The United States Essay2058 Words   |  9 Pagesthe right. Over the years, homelessness has developed in size and complication in Canada (Gaetz, Tarasuk, Dachner, Kirkpatrick, 2006). Originally, the homeless crisis was a major concern of urban centers like Montreal, Laval, Vancouver, Edmonton, Calgary, and Toronto, but rising frequency of homelessness in the suburbs is compelling an immediate response (Laird, 2007). In response to the surmounting homelessness that Canada is facing, the Federal Government of Canada proposed $120 million annuallyRead MoreThe Effects Of Homeless Conditions, Drug Abuse, And Mental Illness1464 Words   |  6 Pagesconditions, self-medication and Homelessness. Depending on the severity of the psychiatric disorder, circumstances can lead to a homeless situation or nomadic lifestyle. It will also cover issues like h ow these influences affect societal issues such as crime violence, abuse, health troubles and communication difficulties with others due to the problems that these individuals have with their thinking process. Key words: Drug abuse, Mental illness, Self-Medication, Homelessness We must bringRead MoreHomelessness : An Epidemic Across The United States1066 Words   |  5 PagesHomelessness has become an epidemic across the United States of America over the past 40 years. Despite the fact that most individuals are reminded of this problem on a daily basis when they see those without homes on the street, few solutions have been implemented that would fix the causes of this horrendous issue. Funding for programs that assist the homeless and homeless prevention programs is abysmal, while the costs incurred due to such a large homeless population continue to rise. Over the

Wednesday, May 6, 2020

Change and People Free Essays

string(71) " or who would be able to attest to your potential and accomplishments\." Outline for â€Å"The Psychological Impact of Dejobbing† †¢ â€Å"You are what you do† – most Americans are defined in terms of their jobs, connected to a wider community through their jobs, and provided with structure and purpose by their jobs. †¢ What you must learn, for today’s job environment – learn to live with work situations that are not framed by job descriptions and clear reporting relationships. We will have to learn to live with multiple roles, where the role mix changes frequently. We will write a custom essay sample on Change and People or any similar topic only for you Order Now And we will have to find the income we need in such unstable and unpredictable conditions †¢ The most difficult aspect of being laid off or otherwise â€Å"dejobbed† – The hardest part of being laid off is the mental aspect. † In the long run it will probably be the psychological aspect of dejobbing that people find most difficult. Incomes are modular and portable; they can be replaced. Replacing the psychological rewards that jobs have provided is far more difficult. What work gives each of us, cognitively and emotionally – A job gives people parts to play and tells them what they need to do to feel good about their contribution. It gives them a way of knowing when they have done enough, and it tells them when their results are satisfactory. Jobs provide people with a place where they need to show up regularly, a list of things they’ve got to do; a role to play in some larger undertaking; a set of expectations to be measured against. It gives them an everyday sense of purpose, and fulfilling such purpose is a source of self-esteem. For people whose personal lives are not going very well, the job may be the only source of self-esteem. †¢ Relationship between order and change in the world of work today – The art of progress is to preserve order amid change and to preserve change amid order. † It is important to recognize this reciprocal relationship and to understand that change and stability are not in an either-or relationship to one another†¦Without order, change has nothing to work on†¦but without hange, order cannot be maintained through time†¦You can feel this relation between change and order when you ride a bicycle: you need to keep making little turns, or else you won’t travel straight and stay upright for very long†¦what the dejobbed worker needs to look for is neither a way to recover absolute stability, nor a way to live with utter chaos, but a dynamic kind o f order that does not block the flow of change How to give a sense of structure and meaning to your life if you are ever â€Å"dejobbed†: I. Grouping changes: 1. Goals – listing the three most important goals you have now†¦we’re looking for big, comprehensive goals here, not the many little ones. Then, decide what intermediate objectives (no more than three) each of your goals requires you to meet in the near future. Your to-do list comes from these nine objectives, but nine is too many. Prioritize them. Which three need to be done pronto? Which three could wait until next week? Which three simply have to be done sometime pretty soon? Now, take the ‘prontos. What immediate, first step does each of them demand? Write them down. Those are the actions you are going to take this week. 2. Steps – After any big change in your life, you are going to have to reprioritize again, because any big change changes the value you put on everything in your life†¦It’s also important to keep others up to date on what your priorities are, since any change is going to affect other people, too. The minute you start considering others, you will find that priority-setting isn’t a game of solitaire. . Actions – Keeping your priorities in order is easier if you are not being swamped by sudden and unexpected changes understand better than others the implications of changes that have already taken place. 4. Environmental shifts – , it is important to improve your capacity to see disruptive changes coming†¦subtle shifts in the environment that have already taken place but have not yet been fully recognized by the people who will be affected by them†¦The demise of jobs is such a shift:†¦closure of ilitary bases, the massive restructuring of the health care industry,†¦ the end of American dominance in world markets†¦What economic, technological, demographic or cultural changes in your own work environment fall into this 5. Internal audit – conduct an audit of your†¦expectations, habits, contacts and personal â€Å"rules,† in regard to how they affect your ability to handle constant change. For each of these ask yourself, what is hindering you? What is helping you? Expectations: do you have expectations that are continually being violated by the next change, such as: †¢ After this change, things will settle down. †¢ If you are employed by a large organization, you will be insulated from the ravages of constant change. †¢ If you â€Å"do a good job† for your employer, you’ll remain on the payroll. †¢ A human being will always be able to do your job better than a machine will. †¢ The government will step in if the competition from overseas gets too intense. †¢ Long service to an organization will be viewed as a plus. Habits: It is critical for you to stay up to date on the social, technical and economic changes that are likely to have an impact on the kind of work you do†¦decide what periodicals you would read, and what professional or trade meetings you would attend, if you were an independent professional in the field. †¢ Contacts: Are you ready to launch a personal business-development effort tomorrow by contacting the first two or three of the several dozen people who could help you move in whatever direction you decided was appropriate? These would be people who, themselves, have contacts; or who know a lot about something you need to understand; or who might be partners in a joint venture, or who have resources you might be able to use, or who would be able to attest to your potential and accomplishments. You read "Change and People" in category "Essay examples" †¢ Personal â€Å"Rules†: Most of us are still playing under the old rules. You need to keep an eye out for them via your self-audit and replace them when find them; rules such as: †¢ Don’t leave a job when good jobs are hard to get. Remember, your present job is only temporarily expedient†¦it is going to disappear. The best jobs go to the people with the best qualifications. This is a half-truth, because the whole idea of â€Å"qualification† is changing. The old ‘qualifications’ included degrees or other formal certification, experience in a similar job, and recommendations. Today, most recommendations are known to be hot air or tail-covering platitudes. Experience is more likely to produce a repetition of the past than the kind of new approach that today’s conditions demand. And there often isn’t any degree or certification in the activity that today’s organization needs. The new meaning of â€Å"qualification† is – your D. A. T. A. †¢ Don’t try to change careers after forty. †¢ Getting into the â€Å"right business† assures a secure future†¦designating any field (as the â€Å"right† one) would be bad advice because although there are parts of the economy that are destined to expand, no part of the economy immune to dejobbing. †¢ It doesn’t matter what you want; it’s what â€Å"they† want that counts. Most of us were raised on this one. Maturity was a matter of tempering our wants and of conforming to what someone with more influence and resources wanted of us. But today, it doesn’t matter nearly as much what an organization wants as it used to. The power has moved elsewhere; the only â€Å"they† that matters much any more is, customers. †¢ You have to be a salesman to get ahead today. Not necessarily, but what you do need is†¦a clear understanding of why someone needs what you have and do, and the ability to make your case effectively. Many people who do those well have no experience or interest in sales as a field. II. Changes in how work-related words are being defined: 1. â€Å"Qualification† – 2. â€Å"Risky† vs. â€Å"responsible† employment – III. Frames of meaning: 1. Identity/integrity – is about psychological rather than ethical. It means wholeness With so much change and fragmentation in the new career world, you need a solid core of self. You have to be true to who you are; to your identity. Here, â€Å"identity† means sameness. It refers to the thread of being-the-same-person that runs through all the actions and relationships and statements of an integrated person. Thus the integrity/identity frame is capable of both maintaining continuity and containing change†¦It is the thread of sameness on which differing activities can be strung The life journey – The first is a journey toward some external goal: influence and power, a happy family, salvation, or self-actualization. The characteristic of this journey is that it has a recognizable destination that is so desirable that we are willing to put up with the hardships along the way. Those hardships are just hurdles or barriers to be overcome. We may even see barriers as â€Å"filters† that keep the impure, the undeveloped or the basely motivated from reaching the valuable goal. We may also view them as filters that screen out those elements in ourselves, in which case we say that the journey made us better people. On this second type of journey we are trying to become the people we are meant to be. We’re â€Å"ugly ducklings† who don’t know that we are really swans†¦we fail to see that most of what the â€Å"great people† of the world have accomplished was not done because they were different but because they were not busy trying to be somebody else. Most of what has been worth doing†¦was accomplished by people who were (like you and me, most of the time) self-doubting, ambivalent and more than a bit discouraged. This second type of journey frames the difficulties along the way no so much as hurdles to be cleared as signals to be attended to, or even lessons to be learned†¦When someone on this journey says that â€Å"there are no accidents,† that does not mean hat we are living according to some great computer program in the sky, but simply that those times when â€Å"the wrong thing happens† are simply the times when we are looking at the world through the filters formed by our outgrown expectations. It means that if we could see the accidental as if it were part of a lesson plan, Our original goals and expectations are little more than the â€Å"bait† that lure us into whatever is the next leg of the journey. Anyone who has come to appreciate these things and can see how often the life journey includes or even depends upon events and situations that we didn’t really want to happen can appreciate the definition of the journey offered by an anonymous sage: â€Å"A journey is a trip after you’ve lost your luggage. 1. Where you place your loyalties – As people get tossed around in the changes that are constantly happening in today’s organizations, they lose their loyalty to organizations and increase their loyalty to the kind of work they do. This constitutes a shift in the continuity-producing frame. The organization can no longer perform that task, since the individual’s connection with it is too easily broken. Only something portable can , so the profession, the vocation, or the work becomes the frame. In another version of the same process, â€Å"professional growth† becomes the frame. Here the work and the journey metaphor are blended, as the changes that the person encounters are translated into chances to learn more about one’s vocation†¦The journey of increasing expertise and the journey toward mastery become personally meaningful frames, for they contain and give meaning to not only one’s achievements, but even to very serious work-related failures and disappointments. 2. Reality† – Quantum physics has taught us to think in terms of energy fields rather than solid matter, and has show us that some life changes occur not gradually or piecemeal as ordinary experience would suggest, but in â€Å"quantum leaps† wherein a pattern of energy moves suddenly from one state or level to another. Life sometimes has that quality – we wake up one morning and â€Å"everything has changed. † The career that looked fine yesterday is today trivial and worthless. The relationship that was very important to us yesterday suddenly isn’t. Or perhaps chaos theory provides an more effective metaphor. If the organization is not like a set of children’s building blocks, all horizontals and verticals on the organizational chart, perhaps the organization is more like flowing water†¦Ã¢â‚¬ Points† are unreal; it’s all flux. The patterns are like weather systems, only predictable in the very short term – yet undeniably ordered by some principle beyond randomness. Contemporary chaos theory talks about so-called strange attractors, which are the ordering principles within such apparently random patterns. They are found in water flows, in the seasons, in the rise and fall of animal populations, in the behavior of financial markets†¦Such a ‘frame’ has the feel of life, its messiness-without-meaninglessness, its constant change and continuous transformation†¦ Create â€Å"Islands of Order†: One of the ways to manage a life of constant change is to maintain stability in some areas your life by not letting change into them†¦some people whose careers have taken them all over the world have kept a home base somewhere that they return to whenever they need to put the pieces back together again. Many people whose work associates come and go†¦keep a circle of friends which changes very little. Many people who go through professional identities as though they were seasonal clothing maintain a spiritual discipline†¦or play a sport seriously. These are the solid points of contact are their rock, which enable them to move safely. Other islands of order are temporal and periodic: quiet time every weekend, every other weekend, one weekend every month; a half-hour of meditation or solitary exercise every morning; two or three weeks â€Å"away from it all† every summer. Some time-outs are occasional: a break, a totally free and passive period at the end of every big project. Some are spontaneous: a sudden decision to spend the afternoon at a movie, take a hike or swim, instead of working. Other islands of order are spatial. They are places where the person goes to break the pattern of constant change. It may be a little park near where you work that you stop by every lunch hour. It may be a room (even a corner of a room) in your house or a chair under a tree in the backyard. It may be a motel room you rent at the beach. Whatever and wherever they are, these are places of order, where you take a break from constant input and output. Still other islands of order are created by favored activities. They may be hobbies†¦stamp collecting†¦playing a musical instrument or a sport†¦cooking, listening to music, taking walks, gardening, doing carpentry, brushing a horse, or training a dog. The common element is that time slows down, even stands still, when you do them. How to cite Change and People, Essay examples

Sunday, May 3, 2020

Amyloid Hypothesis of Alzheimer Disease

Question: Discuss current thinking on the amyloid hypothesis of Alzheimer's disease and how this has impacted treatment strategies for Alzheimer's. Briefly consider whether new hypotheses and treatment targets should be considered for this neurodegenerative disease. Answer: Introduction Alzheimers disease affects the brain as a result of a regenerative disorder. This then causes loss in memory, thinking and alteration in behavior patterns and is regarded as the largest cause of dementia cases. The patients who are suffering from this disease require the provision of services from resource rich health facilities (Pohanka, 2014). The most affected population is the elderly people although a small proportion of young people are also affected by Alzheimers disease. This paper therefore explores alzehaimers disease amyeloid hypothesis in respect to the progress towards the development of treatment options. The amyeloid hypothesis of Alzheimers disease The amyloid hypothesis argues that when the amyloid beta peptides occur in the brain tissues, they lead to the development of the Alzheimers disease. This peptide cause autosomal forms of mutations in three regions namely: presenelin 1, 2 and the amyeloid precursor proteins. The association between this disease and amyloid beta peptide was upon the examination of brain where plaques were found (Selkoe and Hardy, 2016). Therefore, the amyloid cascade provides an explanation to the process via which the Alzheimers disease occurs. These include the genetic causes via mutations, phenotypes and pathology as well as the risks involved. There have been therapeutic drugs produced to target this peptide so as to lower its levels of production. This is expected to cause a clearance in the amounts and levels of amyloid beta protein which in turn should reduce the aggregation of peptides to form plaques. However, it is not clear on the amount of the amyloid peptide which is found in the brain. Something that needs to be noted is that the amyloid beta peptides are the primary components of the neurotic plaques in the brain tissues of the patients who have Alzheimers disease. This is due to the fact that different parts of the brain can carry different amounts of the amyloid peptide and the Alzheimers disease is normally heterogeneous (Drachman, 2014). Another close association between this peptide and this disease is from the cloning of the gene which encodes beta amyloid precursor protein as well as its location in the chromosome number 21. Moreover, it has been found that Downs syndrome leads to the neuropathology of Alzheimers disease. With time, the genetic mutations in the amyloids precursor protein have be found to be a key factor in the development of Alzheimers disease. Since the amyloid beta peptide has been found to be usual product of the metabolism in beta amyloid precursor protein in a persons life, it can be measured by use of a culture medium, plasma and cere brospinal fluid. This measures whether there are any abnormalities which result from the beta amyeloid precursor proteins (Morris et al., 2014). However, recently there have been objections raised against the amyloid hypothesis. One of the objections is that the number of amyloid deposits in the brain tissues does not correlate with the level of cognitive impairments that develops in a patient. In another way, the amyloid hypothesis brings objections since the neurotoxic effects of the amyloid peptide and the effects to the brain have not been studied in vivo. It is also evident that the soluble oligomers of amyloid peptide are responsible for the dysfunction in the brain as opposed the amyloid monomers in Alzheimers disease patients. These and many other objections support a reasoning that the neurodegeneration of the brain in Alzheimers disease is caused by the injury from some diffused oligomeric assemblage of misfolded proteins (Demetrius et al., 2015). As a result of this, the large polymeric aggregates make the inactive reservoirs which are equal to the neurotoxic assembly. On the other hand, the plaques in the brain do not necessarily indicate protection to the host. This is because the observation of these plaques in neurodegenerative diseases means that the reservoir of toxic proteins has occurred in the brain. Experiments involving transgenic mice in which the amyloid beta proteins were deposited in the brain did not indicate any loss in the cognitive abilities. This unexpected behavior by the transgenic mice could be due to differences in the species used, lack of human inflammation mediators and the short period of exposure of mice to the amyloid beta peptide. Since the Alzheimers disease is as a result of lack of balance between the deposition and the clearance of amyloid beta peptides, then there is a need to get treatment strategies for this disorder. One of the approaches would be the inhibition of either the beta or the gamma secretase enzymes which are crucial for the formation of beta amyloids and amyloid precursor proteins (Doody et al., 2014). For the beta secretase, there are some screening which is being done for a chemical compound to find out whether it can be able to bind on the active site of aspartyl protease and hence cross the blood brain barrier. For the gamma secretas e, there are chemical compounds which have already been found but no clinical trials have been done on humans yet. However, it would be advisable to adopt more different treatment approached for the amyloid beta associated Alzheimers disease since the previously proposed strategies have some limitations (Karakaya et al., 2013). For instance a different approach that can be used would involve the use of immunization strategies. The most recommended immunization methods would involve the use of amyloid beta proteins in the cerebral so that they can lower the amounts of peptide clearance from the brain (Aisen and Vellas, 2013). A kind of different approach would involve the use of anti-inflammatory methods and drugs to aid in the clearance of the amyloid beta proteins in brain tissues. The use of the anti-inflammatory methods is recommendable because it has been found that as the amyloid proteins accumulate in brain tissues, the rate of inflammatory process increases. Conclusion For a long period of time, the hypothesis concerning the association of amyloid beta proteins and the Alzheimers disease has been investigated. This calls for the development of therapeutic strategies based on the anti-amyloid beta peptides. In order to get treatment options for this disease. The treatment therapeutics needs to be closely based on the various characteristics that are observed in the amyloid peptides with respect to Alzheimers disease. By the adoption of various methods of treatment involving amyloid precursor protein gene cloning, the scientific world will find out whether there is an association between the amyloid beta protein hypothesis and the Alzheimers disease. Reference List Aisen, P.S. and Vellas, B., 2013. Passive immunotherapy for Alzheimer's disease: what have we learned, and where are we headed?. The journal of nutrition, health aging, 17(1), p.49. Demetrius, L.A., Magistretti, P.J. and Pellerin, L., 2015. Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect. Frontiers in physiology, 5, p.522. Doody, R.S., Thomas, R.G., Farlow, M., Iwatsubo, T., Vellas, B., Joffe, S., Kieburtz, K., Raman, R., Sun, X., Aisen, P.S. and Siemers, E., 2014. Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease. New England Journal of Medicine, 370(4), pp.311-321. Drachman, D.A., 2014. The amyloid hypothesis, time to move on: Amyloid is the downstream result, not cause, of Alzheimer's disease. Alzheimer's Dementia, 10(3), pp.372-380. Karakaya, T., Fuer, F., Schroder, J. and Pantel, J., 2013. Pharmacological treatment of mild cognitive impairment as a prodromal syndrome of Alzheimer's disease. Current neuropharmacology, 11(1), pp.102-108. Morris, G.P., Clark, I.A. and Vissel, B., 2014. Inconsistencies and controversies surrounding the amyloid hypothesis of Alzheimer's disease. Acta neuropathologica communications, 2(1), p.135. Pohanka, M., 2014. Alzheimer s disease and oxidative stress: a review. Current medicinal chemistry, 21(3), pp.356-364. Selkoe, D.J. and Hardy, J., 2016. The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO molecular medicine, 8(6), pp.595-608.Trt